狭基线纹香茶菜对D-半乳糖胺所致大鼠急性肝损伤的保护作用

Protective Effect of Isodon lophanthoides on Acute Hepatic Injury Induced by D-galactosamine in Rats

目的:研究狭基线纹香茶菜对D-半乳糖胺(D-Gal)所致大鼠急性肝损伤的保护作用。方法:60只大鼠随机分为正常对照组、模型组、高中低剂量给药组、阳性对照组。给药组按15、7.5、3.75 g/kg剂量以狭基线纹香茶菜水提物灌胃,阳性对照组按45 mg/kg联苯双酯灌胃,共7 d。灌胃给药第6 d,模型组和给药组按550 mg/kg体重腹腔注射D-Gal一次。第11 d末次给药24 h(腹腔注射36 h)后,测定血清生化指标,并测体重和肝脏重、脾重、胸腺重,求脏器系数,同时切取肝脏检测肝糖原,取肝组织作病理观察。结果:狭基线纹香茶菜可显著降低急性肝损伤大鼠血清ALT、AST、ALP水平和TBA、T-B il含量,促进血清中TP、ALB和肝组织中肝糖原的增加,对肝重量增大和胸腺萎缩有抑制作用,病理检查结果也显示有明显的保肝作用。结论:狭基线纹香茶菜对D-Gal所致大鼠急性肝损伤有保护作用,其作用与多环节有关。

Objective: To study the protective effects of Isodon lophanthoides(ILVG)aqueous extract on acute hepatic injury induced by D-galactosamine(D-Gal) in rats.Methods: 60 rats were divided into control group,model group,and low,middle,high dosage group,Bifendate group randomly.In test groups,rats received either ILVG aqueous extract(15,7.5,3.75 g/kg) or Bifendate(45 mg/kg)by gastric perfusion daily for 7 consecutive days.On the sixth day,D-Gal(550 mg/kg) was given to rats by oral administration.The levels of ALT...