摘要
目的:研究厚朴及厚朴三物汤中和厚朴酚在大鼠体内的药代动力学特征,探讨药物配伍对和厚朴酚在大鼠体内过程的影响。方法:用HPLC法测定厚朴组和厚朴三物汤组中和厚朴酚在大鼠体内的血药浓度,估算二者的药代动力学参数。结果:两组中和厚朴酚在大鼠体内药-时曲线均符合一级吸收二房室模型,主要药代动力学参数AUC、Cmax、Tmax、CL/F等有显著差异(P<0.05)。结论:厚朴三物汤中大黄枳实配伍能影响和厚朴酚的吸收、分布和排泄等。
Objective: To study pharmacokinetics of honokiol in Cortex of Magnolia officinalis and its compound prescription Houpu Sanwu Decoction(HPSWD) in rat,and discuss the change on pharmacokinetic process affected by other components.Methods: The rats were divided into two groups,one was supplied with HPSWD and the other was administrated with Cortex of Magnolia officinalis.Concentrations of honokiol in rats plasma were then determined using HPLC method and main pharmacokinetic parameters were estimated.Results: ...
出处
《中药材》
CAS
CSCD
北大核心
2008年第2期255-258,共4页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金重大研究计划(No:90409010)
国家自然科学基金资助项目(No:30572339)
关键词
厚朴
厚朴三物汤
和厚朴酚
药动学
HPLC
Cortex of Magnolia officinalis
Houpu Sanwu Decoction（HPSWD）
Honokiol
Pharmacokinetics
HPLC
