摘要
目的:确定苦黄颗粒的最佳制剂工艺。方法:以苦黄浸膏软化点的测量数据为指导,结合正交设计,调整喷雾干燥的工艺和流化制粒的工艺,进行苦黄颗粒的制剂工艺研究,筛选出制剂的最佳条件,再以大黄素和大黄酚为指标,采用高效液相法测定含量。结果:苦黄颗粒的最佳制剂工艺为浸膏按100%比例加入糊精,控制进风温度在170℃~175℃,进行喷雾干燥,再选用75%乙醇,在85℃进风温度下以4 Hz流速流化制粒3 h。结论:所选择的最佳制剂工艺较为合理。
Objective: To determine the optimum technology of the Ku Huang granula.Methods: Making Emodin and Chrysophanol for index,using HPLC,extracturm softening point data and orthogonal design experiment to research the preparatory technology of the Ku Huang granula to screen the optimum technology.Results: The Ku Huang granula was pelletized at 100% dextrin,170℃~175℃ spraydrying and at the conditions of 75% ethylalcohol,85℃,4 Hz,3 hours fluidizing pelletization.Conclusion: The optimum condition is reasonable.
出处
《中药材》
CAS
CSCD
北大核心
2008年第2期291-295,共5页
Journal of Chinese Medicinal Materials
关键词
苦黄颗粒
喷雾干燥
工艺研究
Ku Huang granula
Spraydrying
Preparatory technology