聚乙烯吡咯烷酮K30对姜黄素的增溶作用研究

Studies on Solubility Enhancement of Curcumin by Polyvinylpyrrolidione K30

目的:评价聚乙烯吡咯烷酮K30(PVP K30)对姜黄素的增溶作用。方法:选择PVP K30作为载体,用溶剂法制备姜黄素固体分散体;通过差示扫描量热分析和X射线粉末衍射鉴别姜黄素在载体中的存在状态以及与载体之间的相互作用,并采用紫外-可见分光光度法测定姜黄素固体分散体的溶解度以及体外溶出度。结果:紫外-可见分光光度法测定姜黄素的溶出量,利用PVP K30制备姜黄素固体分散体,与姜黄素本身相比,固体分散体中姜黄素溶解度提高了880倍以上,溶出速度明显增大。结论:PVP K30可作为载体以提高姜黄素溶解度及溶出速度。

Objective: To study solubility enhancement of curcumin by Polyvinylpyrrolidione K30(PVP K30).Methods: Solid dispersion systems(SDS) of curcumin in PVP K30 were prepared at various weight ratios by co-evaporation of curcumin and PVP K30 ethanol solution.The differential scanning calorimetry(DSC) and powder Xray diffractometer method were used to describe the status of curcumin in carriers,the UV spectrometry method for determination of curcumin in mediums was established.Results: The curcumin SDS was success...