利福平壳聚糖复合体的制备及表征

Preparation and Characterization of Rifampicin-chitosan Complex

壳聚糖是自然界存在的唯一的碱性多糖,无毒,具有体内生物降解性,其来源于虾蟹类壳,大量使用还能解决沿海虾蟹类壳的去向问题,因此是一种理想可开发的海洋资源。应用壳聚糖制备的缓释剂不仅缓释作用明显,且在体内不会蓄积。利福平对结核杆菌和其他分支杆菌(包括麻风杆菌等),在宿主细胞内、外均有明显的杀菌作用。通过超声波法制备了利福平壳聚糖复合体并用现代分析方法进行了表征,并探讨了在人工胃液中的释药性能。

Chitosan is a kind of alkalescence amylase that existed in the nature exclusively,no poisonous and biodegradable.The large quantity usage can still resolve problem of shell of shrimp and crab along the sea,therefore this is a kind of ideal ocean resource we can research.Sustained release preparation is a new product with many advantages including accurate curative effect,few bad responses,and good patient s compliance.Its are not only provided with good function of sustained-release,but also couldn t accumu...