多环芳烃宫内暴露DNA加合物的形成及相关基因多态性研究进展

Research Advance on Relationship between PAH-DNA Adducts and Gene Polymorphisms, Prenatal Exposure to Polycyclic Aromatic Hydrocarbons

生物标志能促进致癌物质易感性的评价,DNA加合物的形成在多环芳烃致癌过程中是关键的一步。由于多环芳烃在体内要经过代谢活化才能发挥致癌作用,因此不同的代谢酶及造成损伤后的修复过程都会影响到对PAHs遗传效应的评价。动物实验显示,发育中的胚胎可能对多环芳烃的遗传效应更敏感,多环芳烃的宫内暴露可能与多种不良出生结局有关。该文对多环芳烃宫内暴露母婴敏感性的差异、DNA加合物的形成及其与基因多态性之间的关系进行了综述。

The biomarkers can facilitate the evaluation of the factors modulating susceptibility to carcinogens among human populations. As an indicator of DNA damage, carcinogen-DNA adducts represent a critical step on the carcinogenic pathway. Genetic differences in detoxification capabilities and the DNA repair efficiency may modulate PAH-induced DNA damage and carcinogenesis. Experimental animal studies have demonstrated that the fetus and infant are more susceptible to polycyclic aromatic hydrocarbons (PAHs) indu...