甲醛对机体氧化损伤效应影响的研究进展

Research Advance on Oxidation Damage Induced by Formaldehyde

甲醛的毒性研究一直是环境卫生领域研究的热点,它可以通过引起组织活性氧增加、脂质过氧化等途径引起机体的氧化损伤效应,导致脂质过氧化产物丙二醛含量的增加,降低机体不同组织、器官中的超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶的活力及谷胱甘肽的含量,并存在剂量-效应关系。笔者从甲醛在体内的氧化作用机制及对氧化系统的毒性效应方面,综述了近几年国内外关于甲醛对机体氧化系统损伤效应的研究,以便深入探讨甲醛对人体健康的损害,从而保护人群的身体健康。

Reports said formaldehyde could induce the damages of organism and cause the peroxidation of lipids. Formaldehyde inhalation may significantly increase the tissue malondialdehyde concentration and decrease the activity of superoxide dismutase, catalase enzyme, glutathione peroxidase enzyme and the concentration of glutathione in the tissues with a dose-effect relationship. The possible mechanisms of oxidation lesion and the toxic effects of formaldehyde were discussed in the present paper.