饮食因素与女性乳腺癌关系的病例对照研究

Relationship between Dietary Factors and Female Breast Cancer: a Case-control Study

目的探讨饮食因素与女性乳腺癌的关系。方法采用1∶1配比的病例对照研究,对于2004年4月至2005年7月在唐山市各大医院经病理确诊的175例女性乳腺癌患者匹配对照进行一般情况和10a内的饮食摄入情况调查。结果单因素分析显示,每周摄入蔬菜(OR=0.368,95%CI:0.177～0.763)、水果3次以上(OR=0.485,95%CI:0.271～0.867)、每月摄入豆制品3次以上(OR=0.320,95%CI:0.173～0.591)为保护因素,且摄入频率与乳腺癌发病呈剂量-反应关系(经趋势性检验,均P<0.01);多因素分析显示,精神刺激为乳腺癌的危险因素(OR=2.286,95%CI:1.277～4.092);蔬菜(OR=0.591,95%CI:0.401～0.871)、豆制品摄入(OR=0.594,95%CI:0.423～0.833)及生育胎次多(OR=0.249,95%CI:0.087～0.716)为保护因素。结论蔬菜、豆制品的摄入对女性乳腺癌的发生有保护作用。

Objective To explore the relationship between dietary factors and female breast cancer. Methods A 1∶1 matched case-control study was conducted in 175 cases with histopathological diagnosis and 175 matched controls(Apr.2004 to Jul.2005), a questionnaire about general information and dietary intakes over 10 years was used in the present investigation. Results The univariate conditional analysis showed that high intake times of fruits, vegetables and soybean food were the protective factors and the relationshi...