摘要
目的探讨硝酸甘油控制性低血压对罗库溴铵量效关系和恢复时程的影响。方法50例全麻下择期手术,按手术顺序编号,采用随机数字表法分为控制性低血压(deliberate hypotension,DH)组和对照组,每组25例。采用四个成串刺激(TOF刺激)方式监测拇内收肌的收缩反应,记录麻醉手术期间罗库溴铵累计给药法的量效关系(ED50、ED90和ED95,即TOF中第一个肌颤搐(T1%)达到50%、90%和95%抑制所需剂量),追加药物时间间隔、峰效应时间、临床作用时间、作用总时间和恢复指数。结果DH组的ED50、ED90和ED95分别为(141.9±34.7)、(260.8±64.5)和(337.1±81.5)μg/kg,明显低于对照组[分别为(179.8±35.3)、(330.4±72.0)和(401.8±99.5)μg/kg](t=3.828,P=0.000;t=3.600,P=0.000;t=2.515,P=0.015)。DH组量效关系曲线的截距为-4.6±1.2,明显高于对照组-5.7±1.3(t=3.109,P=0.003)。与对照组比较,DH组达到最大抑制效应的时间较长[(2.8±0.6)minvs(2.4±0.5)min,t=2.561,P=0.014]。DH组追加药物的维持时间和恢复时程的峰效应时间、临床作用时间和作用总时间比对照组长,但是差异无显著性(P>0.05)。结论罗库溴铵在硝酸甘油控制性低血压时临床作用强化,起效减慢,但其恢复时程无显著变化。
Objective To study the influence of nitroglycerin-induced deliberate hypotension on the dose-effect relationship and time course of recovery of rocuronium. Methods A total of 50 patients scheduled for elective surgery were numbered consecutively and randomly assigned to deliberate hypotension (DH) or control group (n=25 for each). Thumb adductorius contractile response was monitored with TOF stimulation and the percentage of T depression response was studied. The dose-response relationship of rocuronium was...
出处
《中国微创外科杂志》
CSCD
2008年第3期235-237,共3页
Chinese Journal of Minimally Invasive Surgery
关键词
硝酸甘油
控制性低血压
罗库溴铵
药效学
Nitroglycerin
Pharmacodynamics
Rocuronium
Deliberate hypotension
