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P73基因表达与乳癌细胞凋亡、激素受体的关系 被引量：3

Expression of P73Gene and the Relationship Among P73Gene, Apoptosis and Receptors of Hormone in Breast Cancer
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摘要 背景与目的 :研究P73基因与乳腺癌发病的关系。材料与方法 :应用TUNEL、RT-PCR等技术检测乳癌组织P73基因的表达及其与肿瘤细胞凋亡、激素受体的关系。结果 :45例乳癌组织P73基因表达阳性者32例 ,高于良性乳腺肿瘤 ;淋巴结转移阳性者P73基因表达高于阴性者 ;肿瘤细胞的凋亡率与P73基因表达无相关性 ;P73基因表达与雌、孕激素受体亦无相关性。结论 BACKGROUND&AIM: To investigate the expression of P73gene in breast cancer,also to study the relationship among P73gene,apoptosis and receptors of hormone. MATERIAL AND METHODS: The expression of P73gene in breast cancer tissues was detected by RT-PCR and apoptosis by TUNEL. RESULTS: The expression of P73gene was significantly higher in breast cancer(32/45)than in breast benign tumors(P<0.05)and significantly higher in positive metastasis of lymph nodes than in negative ones(P<0.05);the expression of P73gene...
作者 杨开颜
机构地区 温州医学院附属第一医院病理科
出处 《癌变．畸变．突变》 CAS CSCD 2004年第5期296-297,300,共3页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 温州市科技发展计划项目(No.S2001A29)
关键词 P73 乳腺癌 凋亡 TUNEL RT-PCR P73 breast cancer apoptosis TUNEL RT-PCR
分类号 R737.9 [医药卫生—肿瘤]
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参考文献10

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二级参考文献18

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共引文献3

同被引文献22

  • 1杨开颜,俞康,李剑敏,黄卡特,周韧.乳腺癌组织中p51基因的表达及其意义[J].癌变．畸变．突变,2006,18(3):249-251. 被引量：1
  • 2杨开颜,俞康,李剑敏,陈国荣,黄卡特,朱启建,周韧.P73、P51基因在乳腺癌组织中mRNA的表达及意义[J].中华医学杂志,2006,86(20):1428-1430. 被引量：3
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引证文献3

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癌变．畸变．突变
2004年 第5期

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