还原型谷胱甘肽治疗酒精性肝炎的研究

EFFECT OF REDUCED GLUTATHIONE IN ALCOHOLIC HEPATITIS

目的:观察还原型谷胱甘肽(古拉定)注射剂对酒精性肝炎的疗效。方法:酒精性肝炎患者80例随机分为古拉定治疗组42例,(古拉定1.2g/d,静滴,疗程1月),对照组38例(维生素C3g/d、肝太乐0.6g/d,静滴,疗程1月),分别观察2组治疗1月后血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(-γGT)、血清总胆红素(TBIL)等肝功能恢复情况及症状改善情况。结果:古拉定治疗组总有效率88.1%(37/42),对照组总有效率52.6%(20/38),差异具有显着统计学意义,(P<0.05)。结论:还原型谷光甘肽对酒精性肝炎患者ALT,AST,-γGT,TBIL等异常有良好的治疗作用。

Objective:To evaluate the effect of reduced glutathion in alcoholic hepatitis.Methods: 80 patients with alcoholic hepatitis were randomly divided into the reduced glutathione group(continuously infused wihe 1.2g reduced glutathione daily for 30days) or the contorot group(continuously infused with 2g vitamin C and 0.6g Glucurolactone daily for 30days).Clinical symptoms and the main indices fo hepatic function(ALT,AST,γ-GT,TBIL) were evaluated before and after the treatment.Results:There was significant diffe...