摘要
[目的]探讨急性卒中后抑郁(poststroke depression,PSD)临床生物学的诊断指标。[方法]通过放射免疫方法测定比较血清皮质醇水平。[结果](1)基础血清皮质醇浓度在急性单纯性卒中组及急性PSD组均明显增高,二组之间在增高比率上差异无显著性意义(P>0.05)。(2)地塞米松抑制试验(dexam ethasone suppression test,DST)在PSD组敏感性为68%,特异性为84%,其中轻度PSD组DST敏感性为81%,重度PSD组DST敏感性为53%,均显著高于急性单纯性卒中组DST的敏感性(P<0.01)。[结论]DST可做为急性PSD的实验室生物学诊断检测指标,尤其对轻度急性PSD,其敏感性、特异性高。
[Objective] To explore biological marker for the diagnosis of poststroke depression.[Methods] Cortisol was analyzed with a radionimmunoassay.[Results](1)Baseline serum cortisol was obviously higher.(2)The sensivity of the dexamethasone suppression test was 68% and the specificity 84%,especially in minor poststroke depression the sensivity was 81%.[Conclusion] These data suggested that dexamethasone suppression test may be used as a supplementary marker in the diagnosis of acute poststroke depression.
出处
《大连医科大学学报》
CAS
2007年第3期236-238,共3页
Journal of Dalian Medical University
关键词
PSD
DST
血清皮质醇
poststroke depression
dexamethasone suppression test
serum cortisol
