硬膜外自控镇痛对阑尾炎切除术后患者胃肠激素分泌的影响

Influence of patient controlled epidural analgesia (PCEA) after appendectomy on gastroenteral hormones

[目的]观察急性阑尾炎患者术后硬膜外病人自控镇痛(PCEA)对患者胃动素、胃泌素水平及对胃肠道运动功能的影响。[方法]将急性阑尾炎术后的病人随机分为3组,每组30例,A组术后不镇痛;B组用0.125%的布比卡因、C组用0.125%的罗哌卡因行PCEA,放免法检测3组病人术前和术后胃动素和胃泌素的值。[结果]A、B、C 3组术前,胃动素值分别为(274.65±4.38)、(253.03±4.30)和(248.64±3.12)pg/mL;胃泌素值分别为(128.37±5.42)、(140.12±5.60)和(138.32±4.46)pg/mL,3组之间差异无显著性意义(P>0.05)。A、B、C 3组在术后6 h,胃动素值分别为(201.32±2.84)、(285.63±4.46)和(288.72±3.34)pg/mL;胃泌素值分别为(100.72±3.12)、(168.35±6.32)和(160.54±3.12)pg/mL,B、C 2组两种激素水平均明显高于A组(P<0.05)。[结论]术后应用布比卡因和罗哌卡因行PCEA,均可以促进胃动素和胃泌素的分泌,进而促进胃肠功能的恢复。

[Objective] To observe the influence of PCEA(Patient controlled epidural analgesia) after appendectomy on the gastroenteral hormones,motilin and gastrin.[Methods] Ninety patients were divided randomly into three groups,Group A,the patients without PCEA after appendectomy;Group B,the patients with PCEA using 0.125% bupivacaine;Group C,the patients with PCEA using 0.125% ropivacaine.The levels of motilin and gastrin were detected before and after operations.[Results] Before the appendectomy,the levels of moti...