非特异性基质金属蛋白酶抑制剂多西环素在不稳定性心绞痛中治疗作用的研究被引量：1

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摘要目的探讨非特异性基质金属蛋白酶(MMPS)抑制剂多西环素在不稳定性心绞痛(UAP)中的斑块稳定作用以及对心绞痛的发生频率、心血管事件发生率的影响。方法随机选择两组UAP患者,分为治疗组和对照组,对照组采用常规治疗,治疗组在常规治疗基础上加用多西环素100MG/D,疗程8周。结果治疗组与对照组比较,其减少心绞痛发作频率以及心血管事件发生率均明显优于对照组。两组经统计学处理有显著性差异(P<0.01)。结论多西环素作为MMPS抑制剂有明显斑块稳定作用,可控制UAP的发作和减少心血管事件的发生率,值得临床重视。

作者谭湘明张社兵廖昆

机构地区湘南学院附属医院心内科(心血管疾病研究所)

出处《国际医药卫生导报》 2006年第1期35-37,共3页 International Medicine and Health Guidance News

关键词基质金属蛋白酶多西环素不稳定性心绞痛

分类号 R541.4 [医药卫生—心血管疾病]

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1仲琳,张运.强力霉素在稳定动脉粥样硬化斑块中的作用[J].心血管病学进展,2004,25(4):275-277. 被引量：2
2梅志军,景在平.腹主动脉瘤药物治疗进展[J].临床心血管病杂志,2004,20(7):445-447. 被引量：3
3董波,赵玉霞,颜兆文,陈玉英,宋怀东,黄定九.基质金属蛋白酶-3蛋白及基因在动脉硬化血管中表达意义的研究[J].临床心血管病杂志,2004,20(9):546-548. 被引量：11
4赵强,陈国伟.不稳定型心绞痛患者血清基质金属蛋白酶水平的临床意义——附45例检测报告[J].新医学,2004,35(8):461-463. 被引量：15

二级参考文献50

1[1]Dol F, Martin G, Staels B, et al. Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression and macrophage accumulation in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol,2001,38: 395- 405.
2[2]Tsikouris J P, Cox C D. Pharmacologic blockade of the renin-angiotensin system: vascular benefits beyond commonly understood pharmacologic actions. Pharmacotherapy, 2003,23:1141-1152.
3[3]Reno C, Boykiw R, Luisa M, et al. Temporal alterations in mRNA levels for proteinases and inhibitors and their potential regulators in the healing medial collateral ligament. Biochem Biophys Res Commun, 1998,252:757-763.
4[4]Arroyo L H, Lee R T. Mechanisms of plaque rupture:mechanical and biologic interaction. Cardiovas Res,1999,41:369-375.
5[5]Uzui H, Harpf A, Liu M, et al. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines. Circulation, 2002 , 106:3024-3030.
6[7]Miyazaki M, Takai S. Involvement of angiotensin Ⅱ in development of atherosclerosis. Nippon Rinsho, 2002,60:1904-1910.
7Nagase H,Woessner JF.Jr.Matrix metalloproteinases[J].J Biol Chem,1999,274:21491-21494.
8Greewald RA.Treatment of destructive arthritic disorders with MMP inhibits:potential role of tetracycline[J].Ann Ny Acad Sci,1994,732:181-198.
9Cakir Y,Hahn KA.Direct action by doxycycline against canine osteoma cell proliferation and collagenase(MMP-1) activity in vitro[J].In Vivo,1999,13:327-331.
10Golub LM,Lee HM,Lehrer G,et al.Minocycline reduces gingival collagenolytic activity during diabetes:preliminary observations and a proposed new mechanism of action[J].J Periodontal Res,1983,18(5):516-526.