异丙酚和普鲁卡因对颅内肿瘤切除术病人颅内压的影响

Effects of Propofol Pntravenous Anesthesia and Procaine Balance Anesthesia on ICP

目的研究异丙酚麻醉与普鲁卡因静脉麻醉比较对颅内压的影响。方法拟于全麻下行脑瘤手术病人60例,ASA分级Ⅰ～Ⅱ。随机分异丙酚麻醉组(D组)和普鲁卡因麻醉组(P组)。入室后连续监测HR、ECG、BP、SPO2。L3～4间隙腰大池穿刺,置管,接压力传感器。全麻诱导插管,术中D组使用微泵持续注射异丙酚维持麻醉,P组使用1%普鲁卡因静脉滴注维持麻醉。外科医生开硬膜前及术中询问满意度,以0～100记分。测量平卧后、开硬膜前、开硬膜后的ICP。结果两组病人ICP平卧后D组与PI组比较无显著性差异(P>0.05);开硬膜前D组与P组比较有显著的统计学意义(P<0.001);开硬膜后D组与P组比较有显著的统计学意义(P<0.05);神经外科医师满意度D组与P组比较有显著的统计学意义(P<0.001)。结论本实验证明在降低神经外科手术ICP方面异丙酚静脉麻醉优于普鲁卡因麻醉。

Objective To compare the ICP in anesthesia with propofol or planocaine.Methods 60 cases undergoingintercaranial tumor resection under general anesthesia were enrolled in this research.Among them there were 38male and 22 female cases,aged from 18 to 61 years,weighted from 55 to 85 kg,and heighted from 153 to 182 cm.Allcases, ASA grades were Ⅰ～Ⅱ.Radomly devided into two grops,30 cases each group (D group used propofol and Pgroup used planocaine). Preanesthesia medicine was atropine 0.5mg IM 30 mins before ope...