抗甲状腺药物致粒细胞减少和粒细胞缺乏16例临床分析

A clinical review on 16 cases of Granulocytopenia and agranulocytosis caused by anti-thyroid drug.

目的 分析抗甲状腺药物(ATD)引起的粒细胞减少症(粒减)和粒细胞缺乏症(粒缺)的原因、治疗措施。方法 对16例因ATD引起的粒细胞减少和粒细胞缺乏而住院患者临床资料进行回顾性分析。结果 粒细胞减少及粒细胞缺乏而多发生于用药的3个月内,粒细胞缺乏而均以发热为首发症状,经停用或换用ATD,并用糖皮质激素、重组人粒细胞集落刺激因子(rhG-CSF)升白细胞等综合治疗,预后良好,无1例死亡。在粒细胞缺乏而的治疗中,普遍存在应用解热镇痛药退热治疗及不合理使用rhG-CSF。结论 ATD治疗中应监测血白细胞,尽早发现粒细胞减少及粒细胞缺乏而;在粒细胞缺乏而的治疗中,应慎用解热镇痛药退热治疗,血白细胞恢复正常后及时停用G-CSF。

Objective Researching granulocytopenia and agranulocytosis caused by anti-thyroid drug﹝ATD﹞searching reason ,giving advice to treatment. Methods Researching 16 cases of in-patientclinical documentary of Granulocytopenia and agranulocytosis caused by ATD. Results the Granulocytope-nia and agranulocytosis happened within 3 months after taking ATD,patients always have a temperature atfirst ,stop taking or changing ATD,taking glucocorticoid or recombination human granulocyte colonystimulating factor﹝rhG-CSF﹞...