冠心病患者ApoE基因型与超敏CRP相关性探讨

The study on the interrelation between polymorphism of apolipoprotein E and HsCRP in patients with coronary heart disease

目的 探讨冠心病患者载脂蛋白E(ApoE)基因型与超敏C 反应蛋白 (HsCRP)及胆固醇 /高密度脂蛋白胆固醇 (TC/HDL C)比值的相关性。方法 采用Multi ARMS快速分型法检测 10 5例冠心病患者和 110例正常健康体检者ApoE基因型 ,同时测定其总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、HsCRP、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)的浓度 ,并计算TC/HDL C比值。 结果 冠心病组ε4等位基因频率、HsCRP和TC/HDL C均高于对照组。结论 三者联合检测 ,可进一步预测将来发生冠状动脉综合征的危险性。

Objective To explore the inerrelation between polymorphism of apolipoprotein E and HsCRP in patients with coronary heart disease.Methods Polymorphisms of apoE gene were rapidly detected by Multi-ARMS.Results Comparied with control group,the distribution of apoE3 allele′s frequencies was significantly decreased(P<0.01),but apoE4 alleleallele′s frequencies increased (P<0.01)in coronary heart disease group.There was marked difference in plasma HsCRP and TC/HDL-C among the patients with different apoE ...