aFGF对离体大鼠缺氧/再灌损伤心脏的保护作用被引量：3

Protective effects of aFGF on anoxia/reperfusion injury in isolated rat hearts

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摘要目的:探讨酸性成纤维细胞生长因子(aFGF)对大鼠心脏缺氧/再灌损伤的保护作用及作用机制。方法:在Langendorff装置上建立心脏缺氧/再灌模型,用BL-410生物机能实验系统记录经aFGF预处理的大鼠心脏缺氧/再灌前后左室发展压(LVDP)、左室内压上升/下降的最大、最小速率((dp/dt)m ax、(dp/dt)m in)的变化,测定不同时点冠脉流出液中的乳酸脱氢酶(LDH)、丙二醛(MDA)、超氧化物歧化酶(SOD)含量。结果:aFGF预处理可促进心脏缺氧/再灌后心功能恢复,逆转缺氧/再灌导致的SOD降低和LDH、MDA升高。结论:aFGF对缺氧/再灌损伤心脏具有一定的保护作用,其作用机制可能与提高自由基清除酶活性及抑制脂质过氧化有关。 Aim: To investigate the protective effects and mechanisms of aFGF in anoxia/reperfusion of rat hearts.Methods: Using Langendorff apparatus,we established the model of anoxia/reperfusion of isolated hearts to observe the changes of left ventricle development pressure(LVDP) and the maximum and minium velocity in left intraventricular pressure which is upgrade/descend((dp/dt)_(max)、(dp/dt)_(min))pre-and post-myocardial anoxia/reperfusion were determined,changes of LDH level,SOD activity and MDA level in efflux...

作者李彦李校堃李菁张齐好

机构地区暨南大学医学院病理生理学教研室暨南大学医药生物研究中心

出处《暨南大学学报（自然科学与医学版）》 CAS CSCD 北大核心 2006年第4期531-535,共5页 Journal of Jinan University(Natural Science & Medicine Edition)

基金国家863计划资助项目(No.2002AA2Z3318)

关键词酸性成纤维细胞生长因子缺氧/再灌心肌 acidic fibroblast growth factor anoxia/reperfusion myocardium

分类号 R96 [医药卫生—药理学]

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