摘要
探讨了酸敏感离子通道阻断剂阿米洛利对大鼠脑I/R损伤性炎性反应的影响。采用Zea Longa线栓法建立Sprague-Dawley(SD)大鼠局灶性脑缺血再灌注(I/R)模型,于脑缺血2h再灌注24h时间点测定血清肿瘤坏死因子-α和血浆内皮素的含量。结果显示各组间比较差异有统计学意义:血清肿瘤坏死因子-α:F=9.937,P=0.000;血浆内皮素:F=49.487,P=0.000;阿米洛剂Ⅰ组和Ⅱ组的血清肿瘤坏死因子-α和血浆内皮素较相应I/R模型组低(P<0.05)。这表明,阿米洛利可能通过阻断酸敏感离子通道减轻Ca2超载,降低肿瘤坏死因子-α和血浆内皮素的含量而抑制炎性反应,发挥神经保护作用。
The paper investigates the effects of ASICs blocker on inflammatory reaction in cerebral I/R rats.The model of focal cerebral ischemia-reperfusion(I/R) in Sprague-Dawley(SD) rats was established with sutured-occluded method invented by Zea Longa.Determination to the contents of tumor necrosis factor-α(TNF-α) and endothelin(ET) was at twenty-four hour reperfusion after two hour focal brain ischemia.There were statistical differences in group comparison(TNF-α:F=9.937,P=0.000;ET:F=49.487,P=0.000).The contents ...
出处
《石河子大学学报（自然科学版）》
CAS
2007年第3期345-348,共4页
Journal of Shihezi University(Natural Science)
关键词
脑缺血再灌注损伤
酸敏感离子通道
阿米洛利
炎性反应
cerebral ischemia-reperfusion injury
acid sensing ion channels
Amiloride
inflammatory reaction
