洛沙坦对慢性肺心病肺动脉高压的治疗效应研究

Effect of Losartan in Therapy of Pulmonary Hypertension of Chronic Pulmonary Heart Disease Patients

目的探讨血管紧张素Ⅱ(ATⅡ)在慢性肺心病肺动脉高压发病中的作用和评价其受体拮抗剂洛沙坦对慢性肺心病肺动脉高压的治疗效应。方法以血管紧张素Ⅱ受体拮抗剂洛沙坦对慢性肺心病并肺动脉高压的患者进行治疗,40例患者分为2组:对照组和洛沙坦治疗组,观察两组治疗前后肺动脉压力,右室肥厚和动脉血氧分压的变化以及血浆中ATⅡ浓度的变化。超声心动图检测肺动脉压及右心室内径、采用放免法检测血浆中ATⅡ浓度、血气分析测定PaO2等指标。结果洛沙坦治疗组治疗后与治疗前比较PaO2升高(81.21±4.89 vs 58.68±6.13)、肺动脉压降低(23.42±4.24 vs 32.02±5.08);洛沙坦治疗组治疗后与对照组比较PaO2升高(81.21±4.89 vs 70.68±5.34)、肺动脉压降低更多(23.42±4.24 vs 29.01±5.50)(P均<0.01),而血浆中ATⅡ浓度与对照组比较无显著性差异(P>0.05)。结论血管紧张素Ⅱ受体拮抗剂洛沙坦能扩张血管、降低肺动脉压,并使动脉血氧分压上升,对慢性肺心病具有一定治疗作用。

Objective To discuss the role of ATⅡ in the cause of chronic pulmonary heart disease and to evaluate the effect of losartan,Angiotensin antagonist in the therapy of pulmonary hypertension in chronic pulmonary heart disease.Methods We give the therapy of losartan,Angiotensin antagonist to the patients of chronic pulmonary heart disease,40 patients were randomly divided into two groups: therapy and control.To study the change of the pressure of pulmonary artery,right ventricular with thick wall,arterial blood...