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大肠癌患者血清可溶性E-选择素和细胞间黏附分子-1检测 被引量：1

Detection of serum soluble E-selectin and intercellar adhesion molecule-1 in patients with colorectal carcinoma
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摘要 目的:探讨大肠癌患者血清可溶性E-选择素(sE-selectin)、细胞间黏附分子-1(sICAM-1)检测的意义。方法:采用ELISA检测40例大肠癌患者术前、术后15d、术后30d及20例对照(健康体检者)血清sE-selectin、sI-CAM-1水平。结果:大肠癌患者术前血清sE-selectin、sICAM-1水平高于对照组(P<0.05);术后15d下降,但仍高于对照组(P<0.05);术后30d降至对照组水平(P>0.05)。大肠癌患者血清sE-selectin、sICAM-1水平与淋巴结转移和临床分期有关(P<0.05),与年龄、性别、肿瘤大小及组织学分级无关(P>0.05)。结论:sE-selectin、sICAM-1可能参与了大肠癌侵袭转移过程,是反映大肠癌发生、发展及预后的重要指标。 Aim:To investigate the significance of serum soluble E-selectin(sE-selectin)and intercellar adhesion molecule-1(sICAM-1)detection in patients with colorectal carcinoma.Methods:The serum sE-selectin and sICAM-1 levels in 20 healthy people and 40 patients with colorectal carcinoma pre-operation and 15 days,30 days after operation,were tested by ELISA technique.Results:The serum sE-selectin and sICAM-1 levels in patients with colorectal carcinoma were significantly higher than that of normal control before ope...
作者 张健 王程虎
机构地区 河南省肿瘤医院普外科
出处 《郑州大学学报（医学版）》 CAS 北大核心 2007年第4期728-730,共3页 Journal of Zhengzhou University(Medical Sciences)
关键词 大肠癌 E-选择素 细胞间黏附分子-1 colorectal carcinoma E-selectin intercellar adhesion molecule-1
分类号 R735.34 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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共引文献13

同被引文献6

  • 1张海伶,李红霞,郭文有,马春华,张彦宗.大肠癌中ICAM-1基因的表达及其对预后的影响[J].中国现代医药杂志,2006,8(6):58-60. 被引量：3
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郑州大学学报（医学版）
2007年 第4期

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