硫酸头孢喹肟混悬液在猪体内的药物动力学研究

Pharmacokinetics of cefquinome sulfate suspension in pigs

以健康猪为试验动物,按随机交叉设计试验,肌肉注射头孢喹肟混悬液和静脉注射头孢喹肟溶液,研究其在猪体内的药物动力学。结果表明:肌肉注射的主要药物动力学参数,分布半衰期(T1/2α)为1.33 h,消除半衰期(T1/2β)为4.92 h,表观分布容积(Vd)为0.34 L.kg-1,曲线下面积(AUC)为17.22μg.h.mL-1,达峰时间(tmax)为0.83 h,峰浓度(cmax)为3.36μg.mL-1,生物利用度(F)为93.87%。静脉注射的主要药物动力学参数,T1/2α为0.30 h,T1/2β为2.32 h,Vd为0.13 L.kg-1,AUC为18.35μg.h.mL-1。硫酸头孢喹肟混悬液在健康猪体内的药物动力学特征可归纳为:肌注吸收迅速,达峰时间短,生物利用度高,有效血药浓度可维持24 h。

The pharmacokinetics of cefquinome was investigated in 6 healthy pigs following single intravenous administration of cefquinome solution and single intramuscular administration of cefquinome suspension.The main pharmacokinetic parameters after intramuscular administration were as follows: T1/2α 1.33 h,T1/2β 4.92 h,Vd 0.34 L·kg-1,AUC 17.22 μg·h·mL-1,tmax 0.83 h,cmax 3.36 μg·mL-1,F 93.87%.The main pharmacokinetic parameters after intravenous administration were as follows: T1/2α 0.30 h,T1/2β 2.32 h,Vd 0.13 L·...