摘要
目的:本研究旨在探讨凝血蛋白纤维蛋白原及纤维蛋白溶解的生物标记物纤溶酶原激活物抑制因子(PAI-1)与冠状动脉搭桥术(CABG)后远期死亡率的关系。患者和方法:729例患者于Sahlgrenska大学医院行CABG,术前采血检验纤维蛋白原和PAI-1。对患者随访10年。结果:纤维蛋白原浓度高于中位水平(3.6g/L)的患者与低于中位水平的患者相比,10年死亡率为32.3%vs20.7%(P=0.0005)。
Aim: To explore the association between the coagulation protein fibrinogen and the fibrinolytic biomarker plasminogen activator inhibitor- 1(PAI- 1) and the long-term mortality after coronary artery bypass grafting(CABG). Patients and Methods: In 729 patients undergoing CABG at Sahlgrenska University Hospital, a blood sample for fibrinogen and PAI- 1 was collected prior to the procedure. Patients were followed for 10 years. Results: Among patients with high levels of fibrinogen(>3.6 g/l; median), the 10-...
