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脑梗死患者血清sCD40L的检测及临床意义 被引量:1

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摘要 目的:观察轻中型脑梗死患者血清中可溶性CD40配体(sCD40L)的变化,并探讨其与动脉粥样硬化的关系。方法:采用酶联免疫吸附法测定68例脑梗死患者(其中轻型32例、中型36例)及35例正常对照组血清sCD40L的浓度。结果:脑梗死患者血清sCD40L的水平分别为轻型(1764.16±320.36)ng/ml,中型(2658.56±515.46)ng/ml显著高于健康对照组(1389.60±243.47)ng/ml,中型脑梗死患者血清sCD40L的水平显著高于轻型脑梗死患者水平。结论:脑梗死患者血清sCD40L水平异常,可能是动脉粥样硬化的危险因素,可通过血清sCD40L水平来估测动脉粥样硬化程度,进而预测脑梗死发生的可能性及严重程度。
出处 《实用医技杂志》 2007年第15期1996-1997,共2页 Journal of Practical Medical Techniques
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参考文献4

  • 1Thienel U,Loike J,Yellin MJ,et al.CD154(CD40L)induces Hu-man endothelial cell chemokine production and migration of Leuko-cyte subsets[].Cellular Immunology.1999
  • 2Mach F,Schonbeck U,Sukhova G K,et al.Functional CD40Ligand is expressed on human vascular endothelial cells,smooth Muscle cells,and macrophages:implications for CD402CD40Ligand signa-ling in atherosclerosis[].Proceedings of the National Academy of Sciences of the United States of America.1997
  • 3Ross R.Athensclerosis-an inflammation disease[].The New England Journal of Medicine.1999
  • 4Bruemmer D,Riggers U,HolzmeisterJ,et al.Expression of CD40in-vascular smooth musclec ells and macrophagesis Associated with ear-ly development of human atherosclerotic lesions[].The American Journal of Cardiology.2001

同被引文献19

  • 1Tabara N,Imaizumi T,Yirmani R,et al.Clinical feasibility of mo-lecular imaging of plaque inflammation in athemsclerosis.J NuclMed,2009,50(3):331-334.
  • 2Santilli F,Basilis,Feffonip,et al.CD40/CD40L system and vascu-lar disease.Intern Emerg Med,2007,2(4):256-258.
  • 3Charalambos Antoniades,MD,Constantinos Bakogiannis,MD,Dimitris Tousoulis,MD,et al.The CD40/CD40 Ligand SystemLinking Inflammation With Atherothrombosis.Journal of the A-merican College of Cardiology.2009,54(8):670.
  • 4Jin Y,Nonoyama S,Morio T,et al.Characterization of solubleCD40 ligand released from human activated platelets.Med DentSci,2001,48(1):23-27.
  • 5Charkrabartl S,Blair P,Freedman JE.CD40-CD40L signaling invascular inflammation.J Biol chem,2007,282(25):18307-18317.
  • 6Yuan M,Ohishi M,Wang L,et al.Association between serumlevels of soluble CD40/CD40 ligand and organ damage in hyper-tensive patients.Clin Exp Pharmacol Physiol,2010,23(4):344-353.
  • 7Plaikner M,Peer A,Falkensammer G,et al.Lack of associationof soluble CD40 ligand with the presence of acute myocardial in-farction or ischemic stroke in the emergency department.ClinChem,2009,55(7):175-178.
  • 8Missiou A,Wolf D,Platzer I,Ernst S,Walter C,Rudolf P,et al.CD40L induces inflammation and adipogenesis in adipose cells apotential link between metabolic and cardiovascular disease.Thromb Haemost,2010,103(2):985-988.
  • 9Ferro D,Loffredo L,Polimeni L,et al.Soluble CD40ligand pre-dicts ischemic stroke and myocardial infarction in patients withnonvalvular atrial fibrillation.Arterioscler Thromb Vasc Biol,2007,27(12):2763-2768.
  • 10Mami Ishikawa,Thorsten Vowinkel,Karen Y,et al.CD40/CD40 ligand signaling in mouse cerebral microvasculature afterfocal ischemia/reperfusion.Circulation,2005,111(3):1690-1696.

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