摘要
背景:冠状动脉钙化斑块是动脉粥样硬化斑块负荷的标记物,可预测未来发生心血管事件的风险。作者在一项随机化临床试验中研究了雌激素治疗与冠状动脉钙化之间的关系。方法:在对已行子宫切除的女性接受结合型马雌激素(0.625mg/d)与安慰剂进行比较的女性健康倡议试验的一项辅助性亚组研究中。
BACKGROUND: Calcified plaque in the coronary arteries is a marker for atheromatous-plaque burden and is predictive of future risk of cardiovascular events. We examined the relationship between estrogen therapy and coronary-artery calcium in the context of a randomized clinical trial. METHODS: In our ancillary substudy of the Women s Health Initiative trial of conjugated equine estrogens(0.625 mg per day) as compared with placebo in women who had undergone hysterectomy,we performed computed tomography of th...
