摘要
背景:阿司匹林的抗血小板作用源于对血小板环氧合酶-1的抑制。然而冠状动脉疾病患者中阿司匹林抵抗的发生率以及阿司匹林剂量对血小板抑制的影响仍有争议。
BACKGROUND -The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1 inhibition. Controversy exists on the prevalence of platelet resistance to aspirin in patients with coronary artery disease and effects of aspirin dose on inhibition. Our primary aim was to determine the degree of platelet aspirin responsiveness in patients,as measured by commonly used methods,and to study the relation of aspirin dose to platelet inhibition. METHODS AND RESULTS -We prospectively studied the effect of a...
