摘要
背景:吸烟是心血管事件的重要危险因素。其潜在机制可能与冠状动脉内皮功能障碍和炎症反应增加有关。本研究旨在检验吸烟与心外膜冠状动脉内皮功能障碍和炎症相关这一假说。方法和结果:纳入881例患者(115例当前吸烟者和766例不吸烟者,其中包括314例既往吸烟者),评估冠状动脉内皮功能对乙酰胆碱的反应。
BACKGROUND -Smoking is a major risk factor for cardiovascular events. One of the potential mechanisms may be related to both coronary endothelial dysfunction and increased inflammatory response. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunction and inflammation. METHODS AND RESULTS -Coronary endothelial function in response to acetylcholine was assessed in 881 patients(115 current smokers and 766 nonsmokers,including 314 previou...
