摘要
目的:冷心脏停搏和再灌注对人类心室基因表达的影响未知。作者检验血液心脏停搏条件下的术中缺血再灌注将导致预示心脏保护反应的独特心肌基因表达这一假说。
Objective: The effects of cold cardioplegic arrest and reperfusion on human ventricular gene expression are unknown. We tested the hypothesis that intraoperative ischemia-reperfusion under conditions of blood cardioplegic arrest would induce a unique myocardial genomic profile indicative of a cardioprotective response. Methods: Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. Results: Expression profiling revealed 3 patterns of gene expression:(1) increas...
