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碘造影剂注射对ST段抬高型心肌梗死患者冠状动脉狭窄百分数的影响以及此影响对于冠状动脉内药物治疗试验的意义

Impact of Iodinated Contrast Injections on Percent Diameter Coronary Arterial Stenosis and Implications for Trials of Intracoronary Pharmacotherapies in Patients With ST-Elevation Myocardial Infarction
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摘要 冠状动脉内应用纤溶、抗血小板和抗血栓药物可溶解血凝块,但尚未研究注射本身的机械力对消除血凝块的可能作用。TITAN-TIMI34研究中,在急诊室(ER)接受普通肝素和阿司匹林预治疗的ST段抬高型心肌梗死患者被随机分配在ER接受依替巴肽治疗(n=131) Administration of fibrinolytic, antiplatelet, and antithrombotic agents by the intracoronary route may disaggregate clot, but the potential role of the mechanical force of the injection itself in decreasing clot burden has not been studied. Patients with ST-segment elevation myocardial infarction who were pretreated in the emergency room(ER) with unfractionated heparin and aspirin in the TITAN-TIMI 34 study were randomized to treatment with eptifibatide in the ER(n=131) versus after diagnostic catheterizati...
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