摘要
背景:L-精氨酸是内皮源性一氧化氮(一种内源性血管舒张因子)的前体。已有小样本、短期研究显示,L-精氨酸补充给药可改善外周动脉疾病(PAD)患者的血管反应性和机体功能。本研究旨在确定长期给予L-精氨酸对PAD患者的血管反应性和功能的影响。
BACKGROUND-l-Arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. l-Arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease(PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of l-arginine on vascular reactivity and functional capacity in patients with PAD. METHODS AND RESULTS-The Nitric Oxide in Peripheral Arterial Insufficiency(NOPAIN) study was a randomized clinical tria...
