摘要
目的:研究在冠状动脉疾病(CAD)患者中,应用硝酸酯是否会导致肱动脉的硝酸酯介导的扩张功能(NMD)受损,而后者是否反映硝酸酯耐受。方法:共243例患者(平均年龄61±12岁,146例男性)在行冠状动脉造影前入选。计算Gensini评分评估CAD严重性。
Aim: To investigate whether nitrate-mediated dilatation(NMD) of the brachial artery could be impaired by the use of nitrates and reflect nitrate tolerance in coronary artery disease(CAD) patients. Methods: A total of 243 patients(mean age 61±12 years, 146 male) were recruited before coronary angiography. Gensini score was calculated to assess the severity of CAD. Flow-mediated dilatation(FMD) and NMD of the brachial artery were measured. Results: NMD progressively decreased from subjects without CAD(control...
