期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

凋亡抑制蛋白Livin的研究进展

PROGRESS OF RESEARCH IN THE INHIBITOR OF APOPTOSIS PROTEIN LIVIN
下载PDF
导出
摘要 Livin是凋亡抑制蛋白家族的新成员,主要通过直接抑制凋亡蛋白酶(caspases)而实现对细胞凋亡的抑制。正常成人组织中很少表达,而在一些恶性肿瘤组织中高表达。研究表明Livin与肿瘤的发生,发展密切相关。本文就Livin的结构,分布,作用等方面的研究进展进行介绍。 Livin is a new member of the Inhibitor of Apoptosis Protein family,and mainly inhibit directly caspases to further inhibit cells apoptosis eventually.It hardly expresses in normal adult tissues,but highly expressed in many Malignant tumers.Results of resear-ches indicate that Livin is closely related with the occurrence and development of tumers.This paper introduces recent researches of Livin in the aspects of the structure,distribution and function.
作者 段磊 宝力道 王茂春 苏秀兰
机构地区 内蒙古医学院附属医院普外科
出处 《内蒙古医学院学报》 2007年第S1期555-559,共5页 Acta Academiae Medicinae Neimongol
基金 国家自然科学基金(30460146)
关键词 凋亡 LIVIN 肿瘤 apoptosis Livin tumor
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献5

二级参考文献30

  • 1[1]Lin JH,Deng G,Huang Q et al. KIAP,a novel member of the inhibitor of apoptosis protein family[J]. Biochem Biophys Res Commun, 2000; 279(3): 820.
  • 2[2]Kasof GM,Gomes BC. Livin,a novel inhibitor of apoptosis protein family member [J]. J Biol Chem, 2001; 276(5): 3238.
  • 3[3]Vucic D,Stennicke HR,Pisabarro MT et al. ML-IAP,a novel inhibitor of apoptosis that is preferentially expressed in human melanomas[J]. Curr Biol, 2000;10(21): 1359.
  • 4[4]Yagihashi A,Asanuma K,Tsuji N et al. Detection of anti-livin antibody in gastrointestinal cancer patients [J]. Clin Chem, 2003;49(7): 1206.
  • 5[6]Yaqoub A,Akram A,Aaron P et al. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern [J]. FEBS Letters, 2001;495(1-2): 56.
  • 6[7]Crnkovic-Mertens I,Hoppe-Seyler F,Butz K. Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene [J]. Oncogene, 2003;22(51): 8330.
  • 7[8]Gazzaniga P,Gradilone A,Giuliani L et al. Expression and prognostic significance of LIVIN,SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer [J]. Ann Oncoli, 2003;14(1): 85.
  • 8[9]Ansell SM,Arendt BK,Grote DM et al. Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma [J]. Leukemia, 2004;18(3): 616.
  • 9[10]Pennati M,Binda M,Colella G et al. Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells [J]. Oncogene, 2004;23(2): 386.
  • 10[11]Liu T,Brouha B,Grossman D. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells [J]. Oncogene, 2004;23(1): 39.

共引文献55

内蒙古医学院学报
2007年 第S1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部