早期应用肺表面活性物质治疗新生儿呼吸窘迫综合征疗效观察

Observing the Effect of Pulmonary Surfactant Early Bringing Down Neonatal Respiratry Distress Syndrome

目的:探讨肺表面活性物质(PS)早期给药对极低出生体重儿呼吸窘迫综合征(NRDS)疗效的观察。方法:对19例患NRDS的极低出生体重儿给予PS治疗并同时进行临床对照实验。结果:NRDS患儿给药后24h PO2/FiO2较用药前明显改善,差异显著(P<0.05),呼吸机参数(除PEEP外)明显下降,差异有显著性意义(P<0.05)。结论:对于极低出生体重儿NRDS,早期给予PS治疗可明显改善近期预后,提高存活率。

Objective: To explorei effect of pulmonary surfactant(PS) in the treatment of neonatal respiratry dstress syndrome(NRDS) in early phase.Method:19 examples low birth weight infants with NRDS were treated with pulmonary surfactant in this controlled clinical trail.Result:After given PS 24 hours,the PO2/FiO2 and parameter of respirator utilization ascended significantly,there were significant difference(P<0.05).Conclusion: The strategy of surfactant treatment in early phase can significantly improve the survival of very low birth weight infants with NRDS.