摘要
目的:从新疆党参中提取、纯化多糖并进行抗肿瘤活性的检测。方法:采用水提醇沉法提取、葡聚糖凝胶G75柱层析法纯化,HPGFC法鉴定分子量。用腹水瘤小鼠检测抗肿瘤活性。结果:得到白色粉末状,无味,溶解于水,分子量(Mw)=98521道尔顿的新疆党参多糖。与环磷酰胺合用具有增效作用。结论:新疆党参多糖与化疗药物合用在肿瘤治疗方面有一定的药用价值。
Objective:To separate and purify polysaccharide from Codonopsis clematidea(schrenk)Clar and research the role of antitumor.Methods:The polysaccharide was extracted with boil water and was precipitated by alcohol,purified by by Sephadex G75,examined with HPLC.The antitumor activity was studied with S180 mouse model.Results:CCP is white color and tasteless.MW of CCP was only 98521.CCP enhanced the antitumor effect of Cyclophosphamide greatly.Conclusions:CCP show antitumor activity in some extent.
出处
《农垦医学》
2007年第6期404-406,共3页
Journal of Nongken Medicine
基金
新疆兵团博士基金(200103)
关键词
新疆党参
多糖
肿瘤
Codonopsis clematidea Clar
polysaccharide
tumour
