培多普利和依那普利治疗原发性高血压的疗效比较

Comparison of perindopril and enalapril in the treatment of essential hypertension

目的:比较培多普利和依那普利治疗原发性高血压的疗效和安全性。方法:将76例高血压患者随机分成两组:培多普利组和依那普利组,疗程24周,观察治疗前后血压的变化。结果:两药均能显著降低血压,培多普利有效率为89.5%,依那普利有效率为81.5%,两者差异无显著性。培多普利的收缩压和舒张压的降压谷/峰比值均大于依那普利。结论:对原发性高血压,培多普利是一种有效、安全且易耐受的降压药,每日1次能维持24 h降压效应。

Objective:To compare the efficacy and safety of perindopril and enalapril in the treatment of essential hypertension.Methods:Sixtysix cases with essential hypertension were divided randomly into two groups:perindopril and enalapril.Treatment lasted for 24 weeks.Parameters of blood pressure was measured before and after treatment.Results:Blood pressure were significantly reduced in both groups.There was no significant difference in responder rates between perindopril treated patients(89.5%)and patients taking enalapril(81.5%).The trough to peak ratios of systolic and diastolic blood pressures of perindopril were greater than that of enalapril.Conclusion:Perindoprilonce daily is effective,safe and well tolerated in hypertensihe patients.