神经节苷脂对急性脑梗死预后及对IL-6和瘦素的影响

The effect of GM-1 on IL-6 and leptin in patients with acute cerebral infarction

目的:观察单唾液酸神经节苷脂(GM-1)注射液对急性脑梗死患者的预后及对其血浆瘦素和白介素-6(IL-6)的影响。方法:将40例急性脑梗死患者随机分为治疗组和对照组。对照组采用常规方法治疗,治疗组加用GM-1静脉输注。用放射免疫法(RIA)测定两组治疗前后血浆瘦素和IL-6的含量变化及患者疗效的变化,并进行比较分析。结果:总有效率治疗组为85%,与对照组70%相比,有统计学意义(P<0.05);治疗组的血浆瘦素水平由治疗前的(9.13±5.36)ng/mL降至(5.93±2.01)ng/mL,IL-6水平由治疗前的(0.21±0.05)ng/mL降至(0.14±0.03)ng/mL,两者均有统计学意义(P<0.01);治疗后两组间比较,血浆瘦素水平为(5.93±2.01)ng/mL,对照组为(8.01±3.24)ng/mL;IL-6水平为(0.14±0.03)ng/mL,对照组治疗后为(0.18±0.03)ng/mL,两者比较有统计学意义。结论:GM-1可降低急性脑梗死患者的血浆瘦素及IL-6水平,改善患者的预后。

Objective:To obseve the effect of GM-1 on IL-6 and leptin in patients with acute cerebral infarction.Methods:Forty patients with acute cerebral infarction were randomly divided into control group treated by routine medicine,and treatment group treated by GM-1.Radioimmune assay was used to determine the level of IL-6 and leptin in two groups pre-and post-therapy;meanwilea,all patients′ neurological defects were scored in pre- and post- therapy.Results:Total effective rate in treatment group was 85% and that was 70% in control group(P<0.05).It was signficantly between the two groups.Leptin from(9.13±5.36) ng/mL to (5.93±2.01) ng/mL in treatment group pre-and post-therapy (P<0.01) and IL-6 was from (0.21±0.05) ng/mL to (0.14±0.03) ng/mL.Following the therapy,the level of Leptin is (5.93±2.01) ng/mL in treatment group (P<0.01),and IL-6 is (0.14±0.03) ng/mL in treatment group and (8.01±3.24) ng/mL in control group and (0.18±0.03) ng/mL in control group(P<0.05) were significantly.Conclusion:GM-1 can reduce the level of IL-6 and leptin and improve the neuro function in patients with acute cerebral infarction.