有创与无创序贯机械通气抢救急性重度有机磷中毒合并中间综合征(附100例临床分析)

An analysis to the sequential mechanical ventilation in acute organophosphours pesticides poisoning with intermediate syndrome

目的:评价有创、无创序贯机械通气对急性重度有机磷中毒合并中间综合征的治疗价值。方法:选择接受有创、无创序贯机械通气治疗的中间综合征患者50例,以同期同样标准的50例单纯有创机械通气(IPPV)的中间综合征患者作为对照组,动态观察两组患者呼吸机相关肺炎(VAP)发生率、有创机械通气时间、总机械通气时间、住ICU时间、总住院时间及总住院费用等情况。结果:有创、无创序贯机械通气治疗急性重度有机磷中毒合并中间综合征效果良好,呼吸机相关性肺炎(VAP)发生率、有创机械通气时间、住ICU时间、总住院时间及总住院费用明显低于对照组(P<0.05)。结论:有创、无创序贯机械通气治疗急性重度有机磷中毒合并中间综合征疗效肯定而又安全可靠,值得在临床推广应用。

To evaluate the possibility and the clinic value of the sequential mechanical ventilation in acute organophosphours pesticides poisoning with intermediate syndrome.Methods:One hundred patients with intermediate syndrome were included in the study.Of them,50 were randomly allocated to receive sequential mechanical ventilation,and the other 50 patients received invasive positive pressure ventilation(IPPV).And ventilator-associated pneumonia(VAP)、the IPPV duration、days in ICU、days in hospital、therapy cost were measured.Results:Compared with IPPV group,sequential mechanical ventilation group had lower rate of VAP、shorter duration of IPPV、fewer days in ICU、fewer days in hospital,and could reduce the therapy cost.Conclusion:This study suggest that the sequential mechanical ventilation is effective and safe to intermediate syndrome.