肺炎支原体肺炎患儿血清TNF-α IL-6 IL-10的水平检测及其临床意义

Detection and Significance of Serum TNF-α IL-6 and IL-10 in Children with Mycoplasma Pneumoniae Pneumonia

目的:探讨支原体肺炎患儿血清中细胞因子、肿瘤坏死因子-α、白细胞介素-6、白细胞介素-10在其发病及肺外损害中的作用与意义。方法:将40例支原体肺炎患儿按病情轻重分为两组,20例为轻型支原体肺炎,20例为重症支原体肺炎。正常对照组20例。采用酶联免疫吸附法(ELISA法)测定患儿急性期血清中肿瘤坏死因子-α、白细胞介素-6、白细胞介素-10的水平。结果:支原体肺炎患儿血清肿瘤坏死因子-α、白细胞介素-6、白细胞介素-10水平在发病急性期明显高于正常对照组,且重症支原体肺炎高于轻型支原体肺炎,P均<0.05,差异均有统计学意义。结论:支原体肺炎病变越严重,急性期血清肿瘤坏死因子-α、白细胞介素-6、白细胞介素-10水平越高。因此检测血清中肿瘤坏死因子-α、白细胞介素-6、白细胞介素-10的水平可作为监测支原体肺炎严重程度及有无合并症的指标。

Objective:To evaluate the relationship between cellular cytokine levels(TNF-α、IL-6 and IL-10)and mycoplasma pneumonia in children.Methods: Forty cases of mycoplasma pneumonia were divided into two groups which twenty cases were severe mycoplasma pneumonia and twenty cases were common mycoplasma pneumonia.Twenty more cases were chosen as normal control.The levels of cellular cytokine(TNF-α、IL-6 and IL-10)in the serum of mycoplasma pneumonia were determined by ELISA.Results: The levels of cellular cvtokine(TNF-α、IL-6 and IL-10)were significant higher in severe mycoplasma pneumonia at acut ephase than those in common mycoplasma pneumonia and control group.P<0.05.Conclusions: The levels of cellular cytokine(TNF-α、IL-6 and IL-10) were a reliable marker in evaluating the severity and having complication or not of mycoplasma pneumonia.