化合物模型构建在毒理学研究中的应用

Application of Chemical Models in Toxicological Study

化学物质在给人们生活带来更加便利、舒适的同时,也给大众健康和公共安全带来了隐患。如何预测化合物的毒性,从而最大程度减少和防治化学物质的危害,是直接关系到我国顺利实施可持续发展战略与建立和谐社会的重大科学与技术问题。因此,对越来越多的新化合物的毒性进行方便、快捷和准确的预测就显得十分必要,化合物预测模型的构建在毒理学研究中具有良好的应用前景。该文综述了化合物的毒性效应、模型构建的种类以及定量构效关系在毒理学研究和实践中的应用与进展。

Human health and public safety are being threatened while chemicals bring convenience and comfortable to our life. How to reduce and avoid the hazard of chemicals via toxicity warning is becoming more and more important. Today it is necessary to estimate new chemicals conveniently, quickly and precisely. The warning model of chemicals in toxicology has a favorable prospect of application. The toxic effect and kinds of models of chemicals and the study of quantitative structure activity relationships (QSAR) in toxicity research were reviewed in this paper.