戊二醛消毒剂及对人体安全性的研究进展

Application and Safety of Glutaraldehyde

戊二醛作为一种高效的消毒剂和灭菌剂,因具有灭菌谱广,效果可靠,低毒、安全,刺激性和腐蚀性小,作用时间长等特点,已被国内医院广泛使用。但在近年的临床应用中发现,戊二醛有明显的黏膜毒性和皮肤刺激性,对人体组织、黏膜、皮肤均有固化作用,影响伤口愈合。笔者综述了戊二醛的理化性质、使用情况、优点及对人体的潜在毒性,为对戊二醛进一步进行研究提供科学依据。

Glutaraldehyde, as a sterilizing agent, is a broad spectrum, reliable effect, low toxicity, thrill and causticity with longer period of validity, so it is widely used in the hospitals. But in clinic application there were increasing evidences that glutaraldehyde has toxicity to human body. It can solidify the tissue, mucous membrane and skin, also affect the healing up of the wound. Physiological property of glutaraldehyde was briefly introduced in this paper and the features in application of glutaraldehyde and the merit and potential toxicity to human body were also presented in details.