神经干细胞分化的调控机制

Regulating Mechanism of Differentiation of Neural Stem Cells

神经干细胞具有高度的自我更新能力、多向分化潜能、迁移能力以及良好的组织融合性等特性,在一定条件下可分化成神经元、星形胶质细胞和少突胶质细胞。因此,神经干细胞分化调控机制的研究对中枢神经系统退行性疾病的治疗及损伤后功能的修复具有重要意义。该文综述了基因及外界环境因素对神经干细胞分化的调控机制。

Neural stem cells which have many characters of high self-renewal, multipotentiality, migration and good histocompatibility could differentiate neurons, astrocyte and oligodendrocyte. Therefore, the research on differentiation mechanisms of neural stem cells should be very important for the therapy of nervous system degenerative diseases and functional recovery of the central nervous system injury. The neural stem cells differentiation mechanisms regulated by the genes and environment were reviewed in the present paper.