HRT对绝经后妇女甲状腺功能及肾上腺功能的影响

Changing pattern of thyroid and adrenal function in postmenopausal women after hormone replacement therapy

目的:了解绝经后妇女甲状腺功能及肾上腺功能的变化,以及激素替代疗法(HRT)对甲状腺功能及肾上腺功能的影响。方法:60例绝经后妇女分为两组,HRT组30例,并以30例绝经后妇女作为对照,测定HRT前及12个月后tT3、tT4、fT3、fT4、TSH及肾上腺皮质醇节律。结果:绝经后妇女HRT前后血tT3、tT4、fT3、fT4、TSH及肾上腺皮质醇均无显著差异(P>0.05),且均属于正常范围内。结论:绝经后妇女甲状腺功能和肾上腺皮质功能不如性腺功能的变化明显,且HRT对其影响不大。

Objective:To investigate the changing pattern of thyroid and adrenal function in postmenopausal women and the relationship between hormone replacement therapy(HRT)and thyroid and adrenal function.Methods:The levels of tT3,tT4,fT3,fT4,TSH and cortisol were measured in 60 cases of postmenopausal women(30 cases in HRT group;30 cases for control group)before and 12 months after HRT.Results:The serum levels of tT3,tT4,fT3,fT4,TSH and cortisol had no significant difference before and 12 months after HRT in postmenopausal women.The values of them were all in normal ranges.Conclusion:change of thyroid and adrenal function was not significant and the impact of HRT on it was not evident.