成人创伤性脑损伤后早期应激性肝损害的临床分析

Clinical Analysis of the Hepatic Stress Injury in Early Stage after Traumatic Brain Injury in Adults

目的探讨创伤性脑损伤后早期应激性肝损害(HSI)发病率、高危因素及预后。方法回顾性分析329例创伤性脑损伤(TBI)患者的临床资料。结果329例中发生早期HSI者49例,占创伤性脑损伤患者的14.9%。HSI的发生率和死亡率与颅脑损伤程度显著相关,与患者性别、年龄、损伤部位和损伤类型等方面无显著关系。结论HSI可在创伤性脑损伤的早期发生,它的出现与损伤程度密切相关,临床预后不良,死亡率增加,应给予高度重视和积极干预。

Objective To investigate the incidence,the risk factors and prognosis of the hepatic stress injury in early stage after traumatic brain injury in adults.Methods Total 329 cases with traumatic brain injury admitted and treated in our department from January 2005 to September 2005 were analyzed retrospectively.Results Forty-nine patients were diagnosed hepatic stress injury(14.9%).There is no difference in age,sex,injury type and site,between Group HSI and the control group.The degree of injury(GCS) in HSI is significantly more severe than the control(P<0.001).The mortality in HSI is increased(P<0.05).Conclusion HSI may appear in early stage after traumatic brain injury.There is close correlation between HSI and the degree of injury.The prognosis is not good,the total mortality is 30.6%.HSI needs more attention and active treatment.