硫酸特布他林联合布地耐德对支气管扩张合并支气管哮喘患者的临床反应性

Clinical Reactivity on Budesonide and Terbutaline Sulfate in the Treatment of Bronchiectasis Complicated with Bronchial Asthma

目的观察硫酸特布他林联合布地耐德雾化吸入治疗对支气管扩张合并支气管哮喘的临床反应性。方法选择98例经HRCT明确诊断为支气管扩张,并且在临床同时有可逆性气道反应-支气管哮喘的患者随机分为两组。治疗组48例给予硫酸特布他林联合布地耐德雾化吸入;对照组50例给予常规治疗。观察用药后两组患者的症状改善、肺功能指标{第1秒最大呼气量(FEV1)、FEV1/FVC%、峰流速(PEF)}的变化。结果治疗组前后症状记分由12.13分下降至5.06分,对照组有11.26分下降至10.21分。治疗4个月后治疗组肺功能各指标(FEV1、FEV1/FVC%、PEF)明显改善(P<0.01)。结论支气管扩张合并支气管哮喘患者在常规治疗基础上,硫酸特布他林联合布地耐德雾化吸入治疗,能有效改善患者临床症状及通气功能,缩短病程。

OBJECTIVE To observe the clinical reactivity of Budesonide and Terbutaline in the treatment of bronchiectasis and bronchial asthma.METHODS 98 patients were divided into two groups randomly,who have reversible airway reactivity-bronchial asthma in clinic while with Bronchiectasis which were clearly diagnosed by HRCT.the Aerosol of a group of 48 patients were given inhaled budesonide and Terbutaline.The control group of 50 patients were given routinely only.The clinical symptoms、lung function(FEV1、FEV1/FVC、PEF) were observed before and after the treatment. RESULTS The symptoms score was decreased from 12.13 to 5.06 in the treatment group and from 11.26 to 10.21 in the control group.After 4 months treatment the lung function were improved more significantly in treatment group than in control group(P<0.01).CONCLUSION Combining inhaled budesonide and Terbutaline with routine therapy in patients with routine therapy in patients with bronchiectasis complicated with bronchial asthma can improve clinical symptoms and lung function.