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LC-MS/MS同位素稀释法测定食品中地西泮和氯丙嗪残留量 被引量：3

LC-MS/MS Isotope Dilution Method Determination of Diazepam and Chlorpromazine Residues in Food
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摘要 This article concentrates on the method of the determination of diazepam and chlorpromazine residue in meat and kidney,by using HPLC-MS/MS.The D6-chlorpromazine was added to sample as an internal standard.Then extracted the sample with acetonitrile,cleaned up the extract through Oasis HLB cartridge.Determination and confirmation is made by means of liquid chromatography-tandem mass spectrometry,using internal standard method.The limit of quantitation of chlorpromazine and diazepam are all 1.0 μg/kg. This article concentrates on the method of the determination of diazepam and chlorpromazine residue in meat and kidney,by using HPLC-MS/MS.The D6-chlorpromazine was added to sample as an internal standard.Then extracted the sample with acetonitrile,cleaned up the extract through Oasis HLB cartridge.Determination and confirmation is made by means of liquid chromatography-tandem mass spectrometry,using internal standard method.The limit of quantitation of chlorpromazine and diazepam are all 1.0 μg/kg.
作者 朱坚 邓晓军 郭德华 李波
机构地区 上海出入境检验检疫局
出处 《分析测试学报》 CAS CSCD 北大核心 2007年第z1期239-241,共3页 Journal of Instrumental Analysis
关键词 LC-MS/MS Isotope dilution DIAZEPAM CHLORPROMAZINE LC-MS/MS Isotope dilution Diazepam Chlorpromazine
分类号 O657-55 [理学—分析化学]
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分析测试学报
2007年 第z1期

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