免疫抑制剂冲击治疗高原Graves眼病的疗效观察

Immunosuppressive Agents for Treatment of Graves Ophthalmopathy at High Altitude

目的:研究免疫抑制剂甲氨喋呤+地塞米松冲击治疗高原Graves眼病的疗效。方法:选择居住地位于海拔2260m～3500m之间的Graves眼病患者60例,随机分为冲击治疗组和对照组,治疗前后两组分别测量患眼的突眼度及眼病症状改善评分。结果:两组患者治疗前后突眼度下降程度比较差别有显著性(P<0.05);两组间不良反应比较,差别有显著性(P<0.05)。结论:甲氨喋呤+地塞米松静点免疫冲击治疗高原Graves眼病,尤其对恶性突眼的治疗,疗效肯定,副作用小,优于糖皮质激素口服治疗。

Objective:To study the therapeutic effects of immunosuppressive agents (Dexamethasone+Methotrexate) on Graves ophthalmopathy at high altitude.Methods:60 patients with Graves ophthalmopathy were selected from 2 260m to 3 500m altitudes in this study, and were divided randomLy into two groups: The shock treatment group (Methotrexate + dexamethasone) and the control group. The exophthalmos was measured and ophthalmopathy improve score was recorded before and after treatment. Results:There was a difference of exophthalmos between before and after treatment (P<0.05) in the two groups. The adverse effect was lower in the shock treatment group than that in the control group (P<0.05).Conclusions: The therapeutic effects of the shock treatment (Methotrexate +dexamethasone) on Graves ophthalmopathy is better than that using Oral glucocorticoid treatment, especially for malignant exophthalmos at high altitude.