转化生长因子-β_1在肝细胞癌中的表达及临床意义

Expression of TGF-β_1 in Hapato Cellular Carcinoma and Its Clinical Significance

目的探讨TGF-β1在肝细胞癌(HCC)的表达和临床意义及在血管生成中的作用。方法对47例经手术病理证实的HCC病灶进行回顾性分析,观察其临床病理特征,包括肿瘤大小、包膜、子灶、门静脉癌栓、肝门淋巴结转移、坏死等。用免疫组织化学方法检测癌组织中TGF-β1和CD34的表达情况。分析评价TGF-β1与上述指标的相关性。结果TGF-β1与MVD明显相关,转移高危组、低分化组TGF-β1蛋白表达率均高于转移低危组、高分化组(P<0.05)。MVD与侵袭转移性、包膜完整性及病理分级明显相关(P<0.05)。结论TGF-β1是促进HCC肿瘤血管生成的重要的血管生成因子,并与侵袭转移有关。

Objective To evaluate the expression,clinical significance and the role of TGF-β1 in Hepato-Cellular Carcinoma(HCC).Methods Forty seven lesions of HCC proved pathologically were included in the study.The clinicopathological features including the size of HCC lesions,enhancement patterns,capsule patterns,intrahepatic daughter foci and tumor emboli in portal veins were studied.The expression of TGF-β1,and CD34 was detected by immunohistochemical SP method.The expression of TGF-β1 was compared with MVD,clinicopathological characteristics of HCC.Results There was significantly positive correlation between the expression of TGF-β1 and MVD,metastasis and Edmandson's grade.MVD was correlated with metastasis,capsulae patterns and Edmandson's grade.Conclusion TGF-β1 play an important role in angiogenesis of HCC,and correlated with tumor invasion and metastasis significantly.