老年人血脂水平与血管性血友病因子及血小板膜糖蛋白的关系

The Relationship between the Plasma Lipids Level and Von Willebrand Factor and the Platelet Membrane Glucoprotein in Aged Patients

目的探讨老年人血脂水平与血管性血友病因子及血小板膜糖蛋白的关系。方法应用ELISA法测定了99例老年高血脂症患者(高TG组32例,高LDL-C组36例,高TC,TG,LDL-C组31例)及32例健康老年对照组的血管性血友病因子(vWF)及血小板膜糖蛋白Ⅱb,Ⅲa(GPⅡb,GPⅢa)水平。结果和对照组相比,老年高血脂症患者(高TG组,高LDL-C组,高TC,TG,LDL-C组)血清vWF均显著高于健康老年对照组;血小板膜GPⅡb分子数/血小板和血小板膜GPⅢa分子数/血小板均明显高于健康老年对照组(P<0.01)。相关分析表明:老年高血脂症组GPⅡb,GPⅢa分别与TG(r分别为0.5218,0.5917)呈中度相关,与LDL-C(r分别为0.7842,0.7914)和vWF(r分别为0.8612,0.8413)呈高度相关。结论高血脂可造成血管内皮细胞功能障碍和损伤,导致血小板的活化,血小板膜糖蛋白(GPⅡb,GPⅢa)的测定对诊断和预防血栓性疾病有着重要价值。

Objective To study the relationship between the plasma lipids level and von Willebrand factor(vWF) and the platelet membrane glucoprotein(GP) in aged patients.Methods The level of vWF and GPⅡb,GPⅢa were tested by ELISA in aged hyperlipoidemia patients then compared with the normal group.Results Compared with the control,the levels of plasma vWF and GPⅡb,GPⅢa in aged hyperlipoidemia patients(high TG group,high LDL-C group,high TC,TG,LDL-C group) were significantly higher than those of the normal(P<0.01).The correlation analysis indicated that the level of GPⅡb,GPⅢa in aged hyperlipoidemia patients has midrange correlation with the TG level(r=0.5218,0.5917 separately),but has high correlation with the LDL-C and the vWF level(r=0.8612,0.8413 separately).Conclusion High level of lipids can destroy the function of vascular endothelial cell and induce the activation of platelet.The determination of the platelet membrane glucoprotein(GPⅡb,GPⅢa) has important value for the diagnosis and precaution of thrombogenic disease.