肺炎嗜衣原体、IL-6与冠心病关系的血清学探讨

Effects of Chlamydophila pneumoniae infection and IL-6 in coronary heart disease

采用血清学的方法观察冠心病(CHD)与肺炎嗜衣原体感染及白细胞介素-6之间相关性并对其致病机理作一简要探讨。用酶联免疫吸附分析(ELISA)技术检测136例CHD患者血清中的肺炎嗜衣原体抗体CP-IgA、CP-IgG、CP-IgM阳性率,并对其中肺炎嗜衣原体阳性者进行IL-6的检测。有64%CHD患者血清特异性CP-IgA呈阳性,与健康对照组的8.8%阳性率差异显著(P<0.01);而CP-IgG和CP-IgM与对照组的阳性率无显著差异(P>0.05);CHD肺炎嗜衣原体CP-IgA阳性者的IL-6明显高于对照组,两者之间有显著的差异(P<0.01)。冠心病病人血清肺炎嗜衣原体抗IgA的高阳性率与冠心病之间存在着有意义的联系,是CP-IgA慢性感染CP的标记物,肺炎嗜衣原体感染参与了冠心病的发生与发展。而炎症因子IL-6水平的升高也提示炎症反应在冠心病的发生以及疾病的发展过程中起着重要的作用。

To reveal correlations between coronary heart disease(CHD) and Chlamydophila pneumoniae(CP) infection as well as interleukin6(IL-6) concentrations.Serum levels of CP antibody,CP-IgA、CP-IgG、CP-IgM,were measured with ELISA in 136 CHD patients samples.Among them,IL-6 concentrations were detected within the patients with positive reaction.The ratio of CP-IgA positive is 64% in CHD and 8.8% in control group(P<0.01).Furthermore, among them,IL-6 concentrations in CHD are also significantly higher than those of control group(P<0.01).There are no significantly difference in the CPIgG and IgM positive ratio between CHD and control group.CP infection and high level of IL-6 are closed related to CHD.They may be the risk factors of CHD.