妊娠合并梅毒回顾分析

A retrospective analysis of pregnancy associated with syphilis

目的 研究妊娠合并梅毒对妊娠结局的影响,降低先天性梅毒发生率.方法 回顾性分析宝安区妇幼保健院妇产科2000年1月～2005年12月引产和分娩的27 461例孕、产妇的检查结果.根据是否抗梅毒治疗,将妊娠合并梅毒患者分为治疗组和非治疗组,治疗组患者进行苄星青霉素治疗,非治疗组患者未进行抗梅毒治疗.结果 妊娠合并梅毒检出210例,其中10例为Ⅰ期梅毒,200例为潜伏期梅毒,发病率为0.76%.治疗组与非治疗组围产儿死亡率分别为15.21%和52.85%,两组妊娠结局有显著性差异(P＜0.01).梅毒儿的发生率分别为20.51%和93.93%,两组比较有显著性差异(P＜0.01).结论 妊娠期梅毒患者及早规范的驱梅治疗可以明显改善妊娠结局和围产儿预后,降低梅毒儿的发生;应该对高危人群进行性健康教育和梅毒血清学筛查.

Objective To investigate influence of syphilis infection during pregnancy on pregnancy outcomes in order ro reduce the incidence rate of congernital syphilis.Methods The serological test results of 27 461 pregnant women admitted to and delivered in the department of gynecology and obstetrics of our hospital from January 2000 to November 2005 were retrospectively analyzed.Pregnant women with syphilis were divided into treatment group and non-treatment group according to whether the woman received antisyphilitic treatment.The pregnant women associated with syphilis in the treatment group were treated by benzathine penicillin G and those in the non-treatment group didn't receive any antisyphilitic treatment.Results 210 pregnant women were diagnosed as pregnancy associated with syphilis by serological examination,of which,10 cases were determined primary syphilis,200 cases were determined latent syphilis.The incidence rate of pregnancy associated with syphilis was 0.76%.The perinatal mortality rates was 15.21% in the treatment group and 52.85% in the non-treatment group,and incidence of congenital syphilis was 20.51% and 93.93%,respectively.There were significant differences between the two groups(both P<0.001).Conclusion Regular and early antisyphilitic treatment for those pregnant women associated with syphilis could significantly improve pregnancy outcome and prognosis of the perineonates and reduce incidence rate of congenital syphilis.The sex health education and serological screening for syphilis among high-risk pregnant women are very necessary.